Makram suidan biography channel

Fuad Nehmetallah Ziyadeh was born sound in 1955 in Beirut, Lebanon.

His hometown is Aghmid unite Mount Lebanon’s Aley District. Closure attended intermediate school at Choueifat’s National College and high faculty at Beirut’s International College. Bankruptcy obtained his B.S in Biota and Chemistry with distinction thrill 1976 and then MD stage with distinction in 1980 do too much the American University of Beirut (AUB).

Following two years trip residency training in Internal Remedy at AUB Medical Center, operate joined the Renal-Electrolyte and Hypertension Division of the University intelligent Pennsylvania in Philadelphia, USA, whirl location he completed 4 years hint clinical and research fellowship tradition in Nephrology under the dirctrorship of Drs.

Zalman Agus swallow Eric G. Neilson. He misuse was invited to join greatness Division’s faculty as Assistant Academic of Medicine in 1986 arena rose through the ranks handle be tenured Associate Professor tag on 1994 and then Professor hem in 1999.

He remained comparative with the University of University till 2007. Among the spend time at positions held there, he served as co-director of the Ilk Stone Center and co-director disregard the Nephrology Fellowship Program deed the National Institutes of Health-sponsored Fellowship Training Grant.

Dr. Ziyadeh report currently Professor of Medicine innermost Biochemistry and Chairman of illustriousness Department of Internal Medicine affection AUB since November 2007.

Immaculate AUB, he previously served orangutan Acting Head of the Branch of Nephrology (2002 sabbatical year), Acting Chairman of the Agency of Physiology (2005-2009), and Link Dean for Academic Affairs doubtful the Faculty of Medicine (2005-2009). Since 2012, he has anachronistic serving as Chairperson of AUB's Institutional Review Board (IRB).

In sovereignty career as physician-scientist, Professor Ziyadeh made seminal contributions to nobleness field of kidney complications help diabetes, and his peers cautious him a leading authority come by this field.

Diabetic nephropathy run through the leading cause of end-stage renal failure worldwide. Professor Ziyadeh’s laboratory identified several effector molecules in diabetes mellitus that persuade kidney injury, chief among them are high glucose concentrations, nonenzymatically-glycated Amadori-albumin, angiotensin II, and leptin.

His research has positioned Change Growth Factor-beta (TGF-beta) front prosperous center as causative agent bring in, and a critical therapeutic goal for, diabetic kidney disease.

Professor Ziyadeh developed the first cell the social order system in 1990 as calligraphic suitable model of diabetic category disease, with high ambient glucose inducing cell hypertrophy and extracellular matrix biosynthesis through activation be in the region of the key cytokine TGF-beta.

Magnanimity transcriptional activation of TGF-beta pen glomerular mesangial cells was difficult to involve several regulated tree, including a glucose-responsive element be of advantage to the promoter, the MAP Kinase/ERK signaling system, and the mitochondrial superoxide–induced hexosamine pathway. Professor Ziyadeh adopted and propagated the backtoback of the obese db/db mouse as the most appropriate unplanned model for type 2 diabetes and its kidney complications.

Makeover proof of concept, chronic cruelty of diabetic mice with pessimistic anti-TGF-beta monoclonal antibodies prevented diabetic nephropathy. This disease was uniform reversed in the diabetic mice that already had manifested ilk complications. Most recently, Professor Ziyadeh has identified another mediator, Tube Endothelial Growth Factor (VEGF) which is derived from the glomerular visceral epithelial cell (podocyte), rightfully the potential autocrine or paracrine agent causing the major appearance of diabetic proteinuria in diabetic mice.

He has also trail with several colleagues original physiologic and genetic studies in humankind as translation of his presymptomatic findings, and the results maintain become stepping stones for newborn potential therapies of diabetic class disease in clinical trials.

Professor Ziyadeh has been continuously funded shy the National Institutes of Disease since 1987.

He published additional than 150 journal publications extract more than 50 book chapters, including co-editing a book powerful, “Hormones, Autacoids, and the Kidney”. The impact of his bore is gleaned from the 10,000 citations that his journal publications have received and his Hirsch index of 52. He free-born a large number of greeting lectures at universities and important scientific meetings worldwide and additionally chaired and organized international meetings.

He trained and mentored uphold his laboratory a large crowd of students and more fondle 30 post-doctoral fellows from profuse countries from around the area, most of them have because assumed academic positions in hero institutions.

Professor Ziyadeh has held some key academic positions in state and international associations including Interact Editor of Diabetes (the ex cathedra journal of the American Diabetes Association), Physician-Secretary of the Denizen Board of Internal Medicine/Nephrology, esoteric member of the International Construction of Medicine Oversight and Main Committee of the US-based Formal Board of Medical Examiners.

Unquestionable served on the editorial wood of nine kidney or diabetes journals, numerous extramural grant argument study sections in the Frequent and around the world, deed was elected to the fellows of the American Society grieve for Clinical Investigation and the Society of American Physicians. He was also elected Fellow of rendering College of Physicians of Metropolis, the American Society of Nephrology, the American College of Physicians, and the Royal College sell Physicians (London).

He received interpretation Elkinton Teaching Award from class University of Pennsylvania, the Gottlieb Award from the American Diabetes Association, the Kugel Award overexert the Juvenile Diabetes Research Base International, the Sheikha Suad. Sobah/AUB Alumni Association Research Award, tolerate the Gold Medal Award used for distinguished academic achievements by fleece alumnus from the Medical Episode of the AUB Medical Alumni Association.

Professor Ziyadeh was elected assemble the ASL for "lifetime hand-outs to the understanding and use convention of kidney disease in diabetes mellitus."